Luijsterburg lab

Publications

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
Van den Heuvel D, Rodríguez-Martínez M, van der Meer PJ, Nieto Moreno N, Park J, Kim HS, van Schie JJ, Wondergem AP, D'Souza A, Yakoub G, Herlihy AE, Kashyap K, Boissière T, Walker J, Mitter R, Apelt K, de Lint K, Kirdök I, Ljungman M, Wolthuis RM, Cramer P, Schärer OD, Kokic G, Svejstrup JQ, Luijsterburg MS.
Cell (2024) Dec (187) 1–19 | link

Transcription-coupled repair of DNA-protein crosslinks depends on CSA and CSB
Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D’Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J.
Nature cell biology (2024) May;26(5):797-810 | link

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair
Kokic G, Yakoub G, van den Heuvel D, Wondergem AP, van der Meer PJ, van der Weegen Y, Chernev A, Fianu I, Fokkens TJ, Lorenz S, Urlaub H, Cramer P, Luijsterburg MS.
Nature structural & molecular biology (2024) Mar;31(3):536-547 | link

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
Van den Heuvel D, Kim M, Wondergem AP, Van der Meer PJ, Witkamp M, Lambregtse F, Kim HS, Kan F, Apelt K, Kragten A, González-Prieto R, Vertegaal ACO, Yeo J-E, Kim B-G, Van Doorn R, Schärer OD, Luijsterburg MS
Proceedings of the National Academy of Sciences (2023) March 14, 120 (11) | link

Unscheduled DNA Synthesis at Sites of Local UV-induced DNA Damage to Quantify Global Genome Nucleotide Excision Repair Activity in Human Cells
Van der Meer PJ, van den Heuvel D, Luijsterburg MS
Bio-protocol (2023) Feb 5; 13(3): e4609 | link

XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Blessing C, Apelt K, van den Heuvel D, Gonzalez-Leal C, Rother MB, van der Woude M, González-Prieto R, Yifrach A, Parnas A, Shah RG, Kuo TT, Boer DEC, Cai J, Kragten A, Kim HS, Schärer OD, Vertegaal ACO, Shah GM, Adar S, Lans H, van Attikum H, Ladurner AG, Luijsterburg MS
Nature communications (2022) Aug 13;13(1):4762 | link

Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders
Jia N, Guo C, Nakazawa Y, van den Heuvel D, Luijsterburg MS, Ogi T
DNA Repair (2021) Oct;106:103192 | link

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation
Van der Weegen Y, De Lint K, van den Heuvel D, Nakazawa Y, Mevissen TET, Van Schie JJM, San Martin Alonso M, Boer DEC, González-Prieto R, Narayanan IV, Klaassen NHM, Wondergem AP, Roohollahi K, Dorsman JC, Hara Y, Vertegaal ACO, De Lange J, Walter JC, Noordermeer SM, Ljungman M, Ogi T, Wolthuis RMF, Luijsterburg MS
Nature cell biology (2021) Jun;23(6):595-607 | link

Transcription-coupled DNA repair: from mechanism to human disorder
Van den Heuvel D, Van der Weegen Y, Boer DEC, Ogi T, Luijsterburg MS
Trends in cell biology (2021) May;31(5):359-371 | link

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair
Van den Heuvel D, Spruijt CH, González-Prieto R, Kragten A, Paulsen MT, Zhou D, Wu H, Apelt K, Van der Weegen Y, Yang K, Dijk M, Daxinger L, Marteijn JA, Vertegaal ACO, Ljungman M, Vermeulen M & Luijsterburg MS
Nature communications (2021). Feb 26;12(1):1342 | link

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
Van der Weegen Y, Golan Berman H, Mevissen TET, Apelt K, González-Prieto R, Heilbrun E, Vertegaal ACO, van den Heuvel D, Walter JC, Adar S & Luijsterburg MS
Nature communications (2020). Apr 30;11(1):2104 | link

Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
Apelt K, Zoutendijk I, Gout DY, Wondergem AP, van den Heuvel D, Luijsterburg MS
Scientific reports (2020) Mar 9;10(1):4332 | link

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair
Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
Cell (2020) Mar 19;180(6):1228-1244 | link

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation
Luijsterburg MS, Typas D, Caron MC, Wiegant WW, van den Heuvel D, Boonen RA, Couturier AM, Mullenders LH, Masson JY, van Attikum H (2017)
eLife (2017) Feb 27;6:e20922 | link