Luijsterburg lab

Publications

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
Van den Heuvel D, Rodríguez-Martínez M, van der Meer PJ, Nieto Moreno N, Park J, Kim HS, van Schie JJ, Wondergem AP, D'Souza A, Yakoub G, Herlihy AE, Kashyap K, Boissière T, Walker J, Mitter R, Apelt K, de Lint K, Kirdök I, Ljungman M, Wolthuis RM, Cramer P, Schärer OD, Kokic G, Svejstrup JQ, Luijsterburg MS.
Cell (2024) Dec (187) 1–19 | link

Transcription-coupled repair of DNA-protein crosslinks depends on CSA and CSB
Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D’Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J.
Nature cell biology (2024) May;26(5):797-810 | link

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair
Kokic G, Yakoub G, van den Heuvel D, Wondergem AP, van der Meer PJ, van der Weegen Y, Chernev A, Fianu I, Fokkens TJ, Lorenz S, Urlaub H, Cramer P, Luijsterburg MS.
Nature structural & molecular biology (2024) Mar;31(3):536-547 | link

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
Van den Heuvel D, Kim M, Wondergem AP, Van der Meer PJ, Witkamp M, Lambregtse F, Kim HS, Kan F, Apelt K, Kragten A, González-Prieto R, Vertegaal ACO, Yeo J-E, Kim B-G, Van Doorn R, Schärer OD, Luijsterburg MS
Proceedings of the National Academy of Sciences (2023) March 14, 120 (11) | link

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation
Van der Weegen Y, De Lint K, van den Heuvel D, Nakazawa Y, Mevissen TET, Van Schie JJM, San Martin Alonso M, Boer DEC, González-Prieto R, Narayanan IV, Klaassen NHM, Wondergem AP, Roohollahi K, Dorsman JC, Hara Y, Vertegaal ACO, De Lange J, Walter JC, Noordermeer SM, Ljungman M, Ogi T, Wolthuis RMF, Luijsterburg MS
Nature cell biology (2021) Jun;23(6):595-607 | link

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients
Apelt K, White SM, Kim HS, Yeo J, Kragten A, Wondergem AP, Rooimans M, González-Prieto R, Wiegant WW, Lunke S, Flanagan D, Pantaleo S, Quinlan C, Hardikar W, van Attikum H, Vertegaal ACO, Wilson BT, Wolthuis RMF, Schärer OD, Luijsterburg MS
Journal of experimental medicine (2021). Mar 1;218(3) | link

Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
Apelt K, Zoutendijk I, Gout DY, Wondergem AP, van den Heuvel D, Luijsterburg MS
Scientific reports (2020) Mar 9;10(1):4332 | link